|
KMID : 0389420100180030201
|
|
Korean Journal of Stress Research
2010 Volume.18 No. 3 p.201 ~ p.208
|
|
|
Effect of Exercise Intensity on Expressions of Tumor Necrosis Factor-? and Interleukin-6 in Rats with Lipopolysaccharide-induced Low-grade Systemic Inflammation
|
|
Kim Dea-Young
Kim Ki-Jeong
Sung Yun-Hee
Seo Jin-Hee
Kim Sung-Eun
Kim Bo-Kyun
Lee Taeck-Hyun
Kim Chang-Ju
Kim Dong-Hee
Choi Hyun-Hee
|
|
|
Abstract
|
|
|
|
In the present study, we investigated the effect of exercise intensity on the expressions of tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6) in the rats with lipopolysaccharide-induced low-grade systemic inflammation. Forty-five male Sprague- Dawley rats were used for the present study. The animals were divided into five groups (n=9 in each group): control group, LPS-treated group, LPS-treated and low-intensity exercise group, LPS-treated and moderate-intensity exercise group, and LPS-treated and high-intensity exercise group. Each training session consisted of one bout of treadmill running for 60 min at 0 degree of inclination. The exercise load of low-intensity was at a speed of 8 m/min, moderate-intensity was at a speed of 14 m/min, and high-intensity was at a speed of 22 m/min. In the present results, the concentrations of TNF-? and IL-6 in the serum were increased by LPS injection. The expressions of TNF-? and IL-6 in the motor cortex and hypothalamic paraventricular nucleus were also increased by LPS injection. Treadmill exercise at all intensities suppressed LPS-induced TNF-? levels in the serum, motor cortex, and hypothalamic paraventricular nucleus. Treadmill exercise at high-intensity enhanced IL-6 levels in the serum, motor cortex, and hypothalamic paraventricular nucleus. Our present study showed that high-intensity treadmill exercise decreased TNF-? level and increased IL-6 level in the serum, motor cortex, and hypothalamic paraventricular nucleus of rats with LPS-induced low-grade systemic inflammation. These results suggest that treadmill exercise at high-intensity may be valuable strategy for overcoming the low-grade systemic inflammation.
|
|
|
KEYWORD
|
|
|
Exercise intensity, Interleukin-6, Tumor necrosis factor-?, Hypothalamic paraventricular nucleus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|